Detalhe da pesquisa
1.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature
; 618(7963): 159-168, 2023 Jun.
Artigo
em Inglês
| MEDLINE | ID: mdl-37225977
2.
Identification of epidermal growth factor receptor-tyrosine kinase inhibitor targeting the VP1 pocket of human rhinovirus.
Antimicrob Agents Chemother
; 68(3): e0106423, 2024 Mar 06.
Artigo
em Inglês
| MEDLINE | ID: mdl-38349161
3.
A small molecule inhibitor of HER3: a proof-of-concept study.
Biochem J
; 477(17): 3329-3347, 2020 09 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32815546
4.
Pluripotent Stem Cell-Derived Hepatocytes Phenotypic Screening Reveals Small Molecules Targeting the CDK2/4-C/EBPα/DGAT2 Pathway Preventing ER-Stress Induced Lipid Accumulation.
Int J Mol Sci
; 21(24)2020 Dec 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-33334026
5.
Discovery of a novel aminopyrazine series as selective PI3Kα inhibitors.
Bioorg Med Chem Lett
; 27(13): 3030-3035, 2017 07 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28526367
6.
Discovery of a series of 8-(1-phenylpyrrolidin-2-yl)-6-carboxamide-2-morpholino-4H-chromen-4-one as PI3Kß/δ inhibitors for the treatment of PTEN-deficient tumours.
Bioorg Med Chem Lett
; 27(9): 1949-1954, 2017 05 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-28347666
7.
Discovery of a series of 8-(2,3-dihydro-1,4-benzoxazin-4-ylmethyl)-2-morpholino-4-oxo-chromene-6-carboxamides as PI3Kß/δ inhibitors for the treatment of PTEN-deficient tumours.
Bioorg Med Chem Lett
; 26(9): 2318-23, 2016 May 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-26996374
8.
Design of selective PI3Kα inhibitors starting from a promiscuous pan kinase scaffold.
Bioorg Med Chem Lett
; 25(13): 2679-85, 2015 Jul 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-25980912
9.
Discovery of 1-(4-(5-(5-amino-6-(5-tert-butyl-1,3,4-oxadiazol-2-yl)pyrazin-2-yl)-1-ethyl-1,2,4-triazol-3-yl)piperidin-1-yl)-3-hydroxypropan-1-one (AZD8835): A potent and selective inhibitor of PI3Kα and PI3Kδ for the treatment of cancers.
Bioorg Med Chem Lett
; 25(22): 5155-62, 2015 Nov 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-26475521
10.
Discovery of 9-(1-anilinoethyl)-2-morpholino-4-oxo-pyrido[1,2-a]pyrimidine-7-carboxamides as PI3Kß/δ inhibitors for the treatment of PTEN-deficient tumours.
Bioorg Med Chem Lett
; 24(16): 3928-35, 2014 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-24992874
11.
A phenotypic screen of Marfan syndrome iPSC-derived vascular smooth muscle cells uncovers GSK3ß as a new target.
Stem Cell Reports
; 18(2): 555-569, 2023 02 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-36669494
12.
Fragment-Based Screening Identifies New Quinazolinone-Based Inositol Hexakisphosphate Kinase (IP6K) Inhibitors.
ACS Med Chem Lett
; 14(12): 1760-1766, 2023 Dec 14.
Artigo
em Inglês
| MEDLINE | ID: mdl-38116421
13.
Discovery of novel imidazo[1,2-a]pyridines as inhibitors of the insulin-like growth factor-1 receptor tyrosine kinase.
Bioorg Med Chem Lett
; 21(16): 4698-701, 2011 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-21775140
14.
Phenotypic high-throughput screening platform identifies novel chemotypes for necroptosis inhibition.
Cell Death Discov
; 6: 6, 2020.
Artigo
em Inglês
| MEDLINE | ID: mdl-32123582
15.
Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable.
Bioorg Med Chem Lett
; 18(16): 4723-6, 2008 Aug 15.
Artigo
em Inglês
| MEDLINE | ID: mdl-18676144
16.
Overcoming obstacles in the implementation of factorial design for assay optimization.
Assay Drug Dev Technol
; 13(2): 88-93, 2015 Mar.
Artigo
em Inglês
| MEDLINE | ID: mdl-25710279
17.
Discovery of (R)-8-(1-(3,5-difluorophenylamino)ethyl)-N,N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide (AZD8186): a potent and selective inhibitor of PI3Kß and PI3Kδ for the treatment of PTEN-deficient cancers.
J Med Chem
; 58(2): 943-62, 2015 Jan 22.
Artigo
em Inglês
| MEDLINE | ID: mdl-25514658
18.
Inhibition of PI3Kß signaling with AZD8186 inhibits growth of PTEN-deficient breast and prostate tumors alone and in combination with docetaxel.
Mol Cancer Ther
; 14(1): 48-58, 2015 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-25398829